THERAPEUTIC EFFECT OF SYNTHETIC PROSTAGLANDIN IN THE TREATMENT OF PYOMETRA IN BITCHES

Abstract

The current research was undertaken to study the therapeutic effect of synthetic prostaglandin in treatment of canine pyometra. Seven bitches were treated with synthetic PGF₂α i.e. Cloprostenol sodium at the dose rate of 1μg/kg body weight once daily for 7 days subcutaneously along with supportive therapy. The physiological parameters like rectal temperature and respiration rate, haematological parameters like total leucocyte count (TLC), neutrophil count and monocyte count and serum biochemical parameters like blood urea nitrogen (BUN), creatinine, aspartate transaminase (AST), alkaline phosphatase (ALP), mean total protein and globulin level which were elevated abnormally prior treatment, decreased to normal range after treatment. Other parameters such as haemoglobin, packed cell volume (PCV), total erythrocyte count (TEC), lymphocyte count and mean alanine transaminase (ALT) levels, those were at low level before treatment increased to normal range in the treatment group bitches in comparison with control group. The intensity of side effects was less severe. Two bitches came to estrus within 2 months of treatment and out of them one conceived on subsequent mating. In six bitches, there was recurrence of pyometra within 4 months of treatment. Use of cloprostenol sodium in treatment of canine pyometra in a higher dose rate for a longer duration will reduce rate of recurrence and improve the conception rate.