UNLEASHING SYNERGISTIC POWER: ANTIBACTERIAL POTENTIAL OF MAGNESIUM OXIDE NANOPARTICLES LOADED WITH ERYTHROMYCIN

Abstract

At present, the escalating threat of antibiotic-resistant bacterial infections has prompted the
exploration of innovative approaches to combat microbial pathogens. This study delves into the synergistic
antibacterial potential of magnesium oxide nanoparticles (MgO NPs) when loaded with erythromycin,
aiming to enhance the efficacy of this conventional antibiotic. In this study, MgO NPs were synthesized
using a facile method and erythromycin was subsequently loaded onto the nanoparticle surface. Next, the
synthesized composite was characterized using various analytical techniques, including UV Visibile
Spectroscopy, Scanning Electron Microscopy (SEM), High Resolution Transmission Electron Microscopy
(HR-TEM) and Electron Dispersive X-Ray Analysis (EDX) to confirm the successful formation and
structural attributes of MgO NPs loaded with erythromycin. Finally, Antibacterial assays were conducted
against a spectrum of clinically relevant bacterial strains (encompass both Gram-positive and Gram-
negative organisms). Minimum inhibitory concentration (MIC) and minimum bactericidal concentration
(MBC) values were determined to assess the potency of MgO NPs loaded with erythromycin, juxtaposed
with free erythromycin to elucidate their potential synergistic interactions. The results demonstrated that
the MgO NPs loaded with erythromycin exhibited enhanced antibacterial activity compared to the
individual components alone. The synergistic interaction between MgO NPs and erythromycin was
evident, leading to a significant reduction in the MIC and MBC values for various bacterial strains. In
summary, this study underscores the promising antibacterial potential of magnesium oxide nanoparticles
loaded with erythromycin as a novel therapeutic strategy. The observed synergistic effects have suggested
that the potential for this composite seems to serve as an effective and innovative solution to combat
antibiotic-resistant bacterial infections, paving the way for further exploration and development in the field
of antimicrobial research.