DESIGNANDCHARACTERIZATIONOFBIOADHESIVEACYCLOVIR HYDROGELINCORPORATINGHONEY,CARBOPOL,ANDCHITOSAN FORPROLONGEDSKINDELIVERY

Authors

  • PurnimaTripathi
  • A.K.Singhai

Keywords:

Acyclovir, Hydrogel, Antiviral Formulation, ,Drug Release

Abstract

Thepresent studyaimed to formulateandevaluateacyclovir-loadedhydrogels for effective topical
deliveryusingaBox–BehnkenDesign(BBD).Seventeenformulations(F1–F17)weredevelopedand
optimizedbasedondrugcontentandspreadability.Amongthese, formulationsF2,F9,andF16were
selectedforfurtherevaluationbasedontheirfavorablephysicochemicalproperties.ThepH,viscosity,
extrudability,andin-vitrodrugreleaseof theoptimizedformulationswereassessedtodeterminetheir
suitabilityfor topicaluse.Thein-vitrodrugreleaseprofilerevealedsustaineddrugreleaseover12to
24hours,withF16showingthehighest releaserate(98.45%),whileF9exhibitedthemostcontrolled
releasepattern.Kineticanalysisconfirmedthat thereleasefollowedfirst-orderandKorsmeyer–Peppas
models, indicatinganon-Fickiandiffusionmechanism.Stabilitystudiesover90daysshowedminimal
changes indrugcontent andviscosity, confirming thestabilityof theoptimized formulationsunder
different storageconditions.Thesefindings suggest that acyclovirhydrogels, particularlyF9, offera
promisingandstablesystemforsustainedtopicalantiviraltherapy.

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Published

2025-12-06

How to Cite

PurnimaTripathi, & A.K.Singhai. (2025). DESIGNANDCHARACTERIZATIONOFBIOADHESIVEACYCLOVIR HYDROGELINCORPORATINGHONEY,CARBOPOL,ANDCHITOSAN FORPROLONGEDSKINDELIVERY. The Bioscan, 20(4), 930–946. Retrieved from https://thebioscan.com/index.php/pub/article/view/4568

Issue

Vol. 20 No. 4 (2025): Volume 20 Regular Issue 4 Oct-Dec (2025)

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.