PATHOGENETIC AND PROTECTIVE ASPECTS OF IMMOBILIZATION STRESS

Abstract

The study of the protective and pathogenetic aspects of immobilization stress remains an important area of modern clinical physiology and pathophysiology. At the current stage of development of experimental and clinical medicine, stress and its accompanying comorbid pathologies are the foundation for a number of psychosomatic diseases. Such disorders are a widespread maladaptive phenomenon. To fully restore central nervous system function after stressful exposure, it was necessary to investigate the mechanisms of post-stress complications and the interrelationships between changes in brain function and metabolism, thereby providing a comprehensive and integrated approach to unraveling the pathogenesis of stress complications. The aim of this study is to comparatively analyze the effects of acute and chronic immobilization stress on tissue-specific changes in central neuronal structures. The results of the study showed that an increase in cortisol, accompanied by a decrease in catecholamines and serotonin, reflects a depleted stress response, while an increase in autoantibodies to proteins and receptors indicates the development of neuroimmune aggression. Analysis of the obtained data confirms that the ELIN test, in combination with hormonal profiling, is a sensitive tool for the early detection of stress-induced disorders and can be used to predict neurodegenerative and psychoemotional disorders associated with chronic stress.

KEYWORDS:

Immobilization stress, central nervous system, ELIN test, pathogenesis, catecholamine, serotonin, autoantibodies to proteins.