COMPARATIVE CYTOTOXIC AND ANTIPROLIFERATIVE EFFECTS OF ACTINIDIA DELICIOSA EXTRACTS ON HEPG2 HEPATOCELLULAR CARCINOMA CELLS

Authors

  • Devasena, B
  • Kiran kumar, S
  • Anitha, W
  • Vickneswari, M
  • Vignesh K

Keywords:

Actinidia deliciosa, HepG-2 cell line, anticancer activity, MTT assay, phytochemicals

Abstract

Herbal medicines derived from natural sources are gaining attention for their potential therapeutic roles in cancer treatment. This study evaluates the anticancer activity of various solvent extracts of Actinidia deliciosa (kiwi fruit) against the human hepatocellular carcinoma (HepG-2) cell line using MTT assay. Five extracts—aqueous, chloroform, ethyl acetate, hexane, and methanol—were tested at concentrations ranging from 25 to 125 µg/mL. Among these, the methanol extract showed the most potent cytotoxic effect with an IC₅₀ value of 22.63 µg/mL after 48 hours. Cytomorphological analysis confirmed morphological changes in treated cells, indicating apoptosis. These results suggest that A. deliciosa, especially its methanol extract, holds promise as a potential natural anticancer agent.

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Published

2025-09-17

How to Cite

Devasena, B, Kiran kumar, S, Anitha, W, Vickneswari, M, & Vignesh K. (2025). COMPARATIVE CYTOTOXIC AND ANTIPROLIFERATIVE EFFECTS OF ACTINIDIA DELICIOSA EXTRACTS ON HEPG2 HEPATOCELLULAR CARCINOMA CELLS. The Bioscan, 20(Special Issue-3), 811–817. Retrieved from https://thebioscan.com/index.php/pub/article/view/4080

Issue

Vol. 20 No. Special Issue-3 (2025): Volume 20 Special Issue 3 July (2025)

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.