HYPOGLYCEMIC EFFECT OF ACETONE EXTRACT OF TERMINALIA ARJUNA ROXB. BARK ON TYPE-2 DIABETIC ALBINO RATS

Abstract

In the present study, hypoglycemic effects of Terminalia arjuna bark extract were seen in high fructose (21%) followed by streptozotocin (40mg/kg BW) induced type-2 diabetic male albino rats. In vivo study showed protective effect of T. arjuna bark acetone extract of towards blood glucose, serum urea, serum createnine, SGOT, SGPT, oral glucose tolerance (OGTT), urine sugar and urine ketone bodies in diabetic rats. Feeding 500 mg/kg BW arjuna bark extract to rats showed better effect for blood and urine parameters as compared to rats fed with 250 mg/kg BW arjuna bark extract. The effect of feeding 500 mg/kg BW arjuna bark extract was found to be almost equal to that of with glimepiride fed diabetic rats. The result indicated that Terminalia arjuna bark acetone extract of have antidiabetogenic and possess hypoglycemic effects in type-2 diabetic rats.