Genetic Insight: PON1-C(L55)/T Polymorphism Elevates Cardiovascular Risk in Women with PCOS

Abstract

Paraoxonase 1 (PON1) is a high antioxidant density (HDL) related enzyme that plays an important function in preventing oxidation of low antioxidant density (LDL) and HDL. PON1 activity have recently been investigated in order to determine its link to cardiovascular disease, diabetes, cancer, infertility, and other conditions. The PON1 gene's variation may influence metabolism, resulting in an imbalance of pro-oxidants and antioxidants. This enzyme's critical involvement may put polycystic ovarian syndrome (PCOS) women at risk for cardiovascular disease. This study looked at samples from 56 healthy women and 53 women with PCOS. The PON1 L55 C/T frequencies were determined using PCR and RFLP experiments. To see if there was a link between the polymorphism and cardiovascular risk, researchers looked at the enzyme activity and polymorphism. Women with the L55 TT genotype (as opposed to L55 C alleles) had lower paraoxonase activity in PCOS patients and controls. The C/T polymorphism in PON1 L55 has been linked to PCOS in women. As a result, it could be a key driver of cardiovascular risk in women with PCOS.