Recent Advances in Novel Drug Delivery System for Antidepressants: Emphasis on Gastroretentive and Sustained-Release Technologies

Abstract

This review article looks at how depression lasts a long time, needing ongoing use of drugs
such as amitriptyline, fluoxetine, sertraline, or duloxetine. Yet, their impact often falls short
because they do not absorb well, break down too quickly in the liver, or people fail to take them
regularly. New ways of giving medicine now help - by changing when and where the drug
releases, keeping it longer in the stomach, and smoothing out levels in the blood. Focus lands
on fresh advances: pills that float, stick to tissue, stay put in the gut, or drip-feed medication
slowly. Methods used to build these forms come under scrutiny - the materials chosen, how the
dose escapes into the body, what scientists are exploring next.