Comprehensive Preformulation, Formulation, and Stability Evaluation of Curcumin Nanoemulsion for Enhanced Bioavailability

Abstract

Background: Curcumin, a polyphenolic compound from Curcuma longa, exhibits potent
therapeutic effects but suffers from poor aqueous solubility, instability, and low oral
bioavailability.1,9,5
Methods: A curcumin nanoemulsion was optimized using a Quality by Design (QbD)
approach with Box–Behnken design. Thirteen formulations were prepared by high-shear
homogenization and ultrasonication, and evaluated for globule size, PDI, zeta potential,
viscosity, pH, refractive index, and in vitro drug release.2,5,10