Comprehensive Preformulation, Formulation, and Stability Evaluation of Curcumin Nanoemulsion for Enhanced Bioavailability

Abstract

Background: Curcumin, a polyphenolic compound from Curcuma longa, exhibits potent therapeutic
effects but suffers from poor aqueous solubility, instability, and low oral bioavailability.1,9,5
Methods: A curcumin nanoemulsion was optimized using a Quality by Design (QbD) approach with
Box–Behnken design.