FORMULATION AND EVALUATION OF EMTRICITABINE FLOATING TABLETS

Abstract

This study aimed to formulate and evaluate floating tablets of Emtricitabine, an antiretroviral drug with a narrow absorption window. Floating drug delivery systems (FDDS) enhance gastric retention and improve bioavailability. Nine formulations (F1–F9) were prepared using HPMC, Guar gum, and Agar by direct compression.Pre- and post-compression parameters were within acceptable limits. Among the formulations, F1 (with HPMC) showed the best performance with 98.4% drug release at 24 hours and an 8-hour floating time. These findings support the potential of floating tablets to enhance Emtricitabine's bioavailability. Further in vivo studies are needed for clinical validation.