HEAVY METAL INDUCED CHANGES OF RAT SERUM NITRITE AND NITRATE LEVELS

C. ASHOKA KUMAR; K. M. UDAY KUMAR,; K. VIJAYA KUMARI; M. RAJESWARA RAO

HEAVY METAL INDUCED CHANGES OF RAT SERUM NITRITE AND NITRATE LEVELS

Authors

C. ASHOKA KUMAR
K. M. UDAY KUMAR,
K. VIJAYA KUMARI
M. RAJESWARA RAO

Keywords:

Heavy metals, Rat serum, Nitrite, Nitrate, Free radical damage

Abstract

Nitrite / Nitrate (NO -
2 /NO -
3 ) are well known to be the end products of nitric oxide (NO) pathway, Keeping in
view the toxic effects exerted by heavy metals, the impact of selected heavy metals on rat serum NO -
3 /NO -
2 levels
is reported. Selected heavy metals like Hg 2+ , Pb 2+ , Cd 2+ , Cu 2+ , Mn 2+ and Al 2+ were selected for the study and albino
rats were treated with an IC 50 dose of each metal. All the metals caused an elevation of rat serum NO -
2 /NO -
3 levels
of rat serum. It is reported that the heavy metals by way of enhancing rat serum NO -
2 /NO -
3 levels may induce free
radical type damage to various organs of rat.

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Published

2013-07-12

How to Cite

C. ASHOKA KUMAR, K. M. UDAY KUMAR, K. VIJAYA KUMARI, & M. RAJESWARA RAO. (2013). HEAVY METAL INDUCED CHANGES OF RAT SERUM NITRITE AND NITRATE LEVELS. The Bioscan, 8(Supplement 3), 1005–1006. Retrieved from https://thebioscan.com/index.php/pub/article/view/374