Formulation and Evaluation of Natural Oil (Turmeric and Chenopodium Oil Nanoemulsion for Effective Treatment of Cancer

Abstract

Background: Turmeric oil and Chenopodium oil are natural oils with much evidence for their therapeutic actions including
anticancer activity. Aim: Present studied was to explore the anticancer activity of nanoemulsion prepared by Turmeric and
Chenopodium oil. Method: Tu-Ch oil nanoemulsion prepared using Tween 80 by ultrasonication. The anticancer activity of
Nanoemulsion estimated by MTT cell viability assay against HeKa Toungue carcinoma cells. Results: To increase the
stability of essential oils through Nanoemulsion. The optimized formulation of Nanoemulsion was studied at increased (oil:
surfactant) ratio and evaluation by analysis of PH, Viscosity, Zeta potential, Poly dispersity index, particle size distribution,
and cell viability at different concentrations. The particle size of developed nanoemulsion (A2) was found to be 172.3 nm,
viscosity of the nanoemulsion formulation was (28.55 ± 2.03mP) and Zeta potential was 0.240 ± 0.05, PDI value -28.0± 0.24
for Tu-Ch oil-loaded nanoemulsion. turmeric oil and chenopodium oils together in nanoscale showed a concentration-
dependent cytotoxicity effect. Conclusion: This study proves that the Combination of Turmeric and Chenopodium Oil
nanoemulsion is a permissible natural medicine that can overcome the drawbacks in cancer treatment.