ENHANCING SOLUBILITY: INNOVATIVE APPROACHES TO ENHANCE SOLUBILITY OF POORLY WATER-SOLUBLE DRUG

Abstract

This investigation aimed to determine the effectiveness of innovative method by using single or double combinatorial technique approach in preparing a solid matrix to enhance the aqueous solubility and dissolution of poorly water-soluble drugs like Curcumin (Cur). In order to use different techniques to improve aqueous solubility of poorly water-soluble drug with beta cyclodextrin (β-CD). The using of different techniques with hydrophilic polymer in different ratio and developed a solid matrix. Solid matrixes were characterized for solubility, in-vitro dissolution, Fourier Transform infrared (FTIR), X-ray diffractometry (XRD), Scanning electron microscopy (SEM). Its enhanced solubility is crucial in the selection of suitable methods for double combinatorial methods approach.