IMPACT OF PHYTOESTROGENS ON ENDOCRINE GLANDS OF CT OF PHYTOESTROGENS ON ENDOCRINE GLANDS OF ALBINO RATS I. PITUITARY

Abstract

Studies have been conducted to determine the impact of estrogenic activities of ethanolic extract of seeds of
Citrus medica on pituitary gland of albino rats. Histological preparations by differential staining pituitary gland
of extract treated sexually immature and ovariectomised female albino rats are observed under light microscope
on the basis of the tinctorial response of different cells. The increased uterine weight and highly developed
uterine glands proved the estrogenic activity of the ethanolic extract of the seeds of Citrus medica. Pars distalis
of pituitary gland of control rats showed presence of significant number of STH cells and moderate number of
LTH cells (acidophils). A number of gonadotrophs were observed. Thyrotrophs were scattered throughout the
pars distalis and were found mainly present towards the periphery while the pars distalis of ethanolic extract
of treated rats showed insignificant changes in the number of acidophils STH and LTH. Thyrotrophs were
granulated and scattered throughout the pars distalis. The numbers of gonadotroph FSH were significantly
increased.