IMPACT OF Pleurotus tuber-regium(Rumph. ex Fr.)EXTRACT LOADED SILVER NANOPARTICLES ON LIPID PROFILE OF MAMMALIAN MODEL,WISTAR ALBINO RATS(Rattus norvegicus)

Authors

  • SUKUMAR DANDAPAT
  • MANOJ KUMAR
  • ROHIT SRIVASTAVA
  • MANORANJAN PRASAD SINHA

Keywords:

Disease, Lipid, Mushroom, Nanoparticles

Abstract

The effect of silver nanoparticles (SNPs) loaded with Pleurotus tuber-regium extract on the lipid profile of Wistar albino rats as mammalian model has been assessed and compared with that of crude extract.The SNPs loaded with P. tuber-regium extract showed significant (p<0.05) increase in HDL (High Density Lipoprotein) cholesterol (52.74±1.12 mg dL-1) in rats treated with 400 mg kg-1 dose (group 3) of nanoparticles in comparison to 200 mg kg-1 dose (group 2)  and control group (group 1). However, a significant decrease (p<0.05) in total cholesterol (65.24±0.70 mg dL-1), LDL cholesterol (29.82±0.29 mg dL-1) and triglyceride (63.91±0.99 mg dL-1) in rats of Group-3 was observed compare to the Group-2 and control group of rats. The results of SNPs treatment, when compared to the crude extract treatment for the similar parameters, have shown significantly (p<0.05) better performance. The medicinal properties of SNPs exhibited better efficacy than the crude extract.  On the basis of the observations, it can be concluded that crude extract of Pleurotus tuber-regium as well as silver nanoparticles loaded with extract of Pleurotus tuber-regium be used in formulation and delivery of drug for hypercholesterolemia.

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Published

2023-03-14

How to Cite

DANDAPAT, S., KUMAR , M., SRIVASTAVA, R., & SINHA, M. P. (2023). IMPACT OF Pleurotus tuber-regium(Rumph. ex Fr.)EXTRACT LOADED SILVER NANOPARTICLES ON LIPID PROFILE OF MAMMALIAN MODEL,WISTAR ALBINO RATS(Rattus norvegicus). The Bioscan, 18(1), 51–54. Retrieved from https://thebioscan.com/index.php/pub/article/view/516