ABDOMINAL MUSCLE LDH IN MICE DURING IMMUNOSTIMULATION AND INDUCED HEPATITIS B

Abstract

Lactate dehydrogenase (LDH) content in the biological systems is indispensably concerned with the tissue
breakdown and cytotoxicity during various aliments. The prime objective in recent medical advances is to
conceptualize the degree of cytotoxicity mainly in human diseases. The present work is centralized on the
impact of Immunex DS on male Swiss albino mice innoculated with various doses of Gene Vac B vaccine. Six
groups of male Swiss albino mice were immunostimulated by Immunex DS and innoculated with various
single doses of Gene Vac B vaccine containing HbsAg, and compared the intense tissue break down and
cytotoxicity in their abdominal muscles. The present findings clearly confirm elevated level of LDH which
correlates with the extent of tissue break down and cell death during induced hepatitis B induction.